AustralieFrV1, Main, Exploration, bibRecord, 001517

Toxicity and quality of life after adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): an open-label, multicentre, randomised, phase 3 trial.

Identifieur interne : 001517 ( Main/Exploration ); précédent : 001516; suivant : 001518

Toxicity and quality of life after adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): an open-label, multicentre, randomised, phase 3 trial.

Auteurs : Stephanie M. De Boer [Pays-Bas] ; Melanie E. Powell [Royaume-Uni] ; Linda Mileshkin [Australie] ; Dionyssios Katsaros [Italie] ; Paul Bessette [Canada] ; Christine Haie-Meder [France] ; Petronella B. Ottevanger [Pays-Bas] ; Jonathan A. Ledermann [Royaume-Uni] ; Pearly Khaw [Australie] ; Alessandro Colombo [Italie] ; Anthony Fyles [Canada] ; Marie-Helene Baron [France] ; Henry C. Kitchener [Royaume-Uni] ; Hans W. Nijman [Pays-Bas] ; Roy F. Kruitwagen [Pays-Bas] ; Remi A. Nout [Pays-Bas] ; Karen W. Verhoeven-Adema [Pays-Bas] ; Vincent T. Smit [Pays-Bas] ; Hein Putter [Pays-Bas] ; Carien L. Creutzberg [Pays-Bas]

Source :

The Lancet. Oncology [ 1474-5488 ] ; 2016.

RBID : pubmed:27397040

Descripteurs français

English descriptors

KwdEn :
- Adenocarcinoma, Clear Cell (radiotherapy), Adenocarcinoma, Clear Cell (secondary), Adenocarcinoma, Clear Cell (therapy), Aged, Antineoplastic Combined Chemotherapy Protocols (adverse effects), Carboplatin (administration & dosage), Case-Control Studies, Chemoradiotherapy, Adjuvant (adverse effects), Cisplatin (administration & dosage), Cystadenocarcinoma, Serous (radiotherapy), Cystadenocarcinoma, Serous (secondary), Cystadenocarcinoma, Serous (therapy), Endometrial Neoplasms (pathology), Endometrial Neoplasms (radiotherapy), Endometrial Neoplasms (therapy), Female, Follow-Up Studies, Gastrointestinal Diseases (diagnosis), Gastrointestinal Diseases (etiology), Hematologic Diseases (diagnosis), Hematologic Diseases (etiology), Humans, Lymphatic Metastasis, Middle Aged, Neoplasm Grading, Neoplasm Invasiveness, Neoplasm Staging, Nervous System Diseases (diagnosis), Nervous System Diseases (etiology), Paclitaxel (administration & dosage), Prognosis, Quality of Life, Radiotherapy, Adjuvant (adverse effects), Survival Rate.
MESH :
- chemical , administration & dosage : Carboplatin, Cisplatin, Paclitaxel.
- adverse effects : Antineoplastic Combined Chemotherapy Protocols, Chemoradiotherapy, Adjuvant, Radiotherapy, Adjuvant.
- diagnosis : Gastrointestinal Diseases, Hematologic Diseases, Nervous System Diseases.
- etiology : Gastrointestinal Diseases, Hematologic Diseases, Nervous System Diseases.
- pathology : Endometrial Neoplasms.
- radiotherapy : Adenocarcinoma, Clear Cell, Cystadenocarcinoma, Serous, Endometrial Neoplasms.
- secondary : Adenocarcinoma, Clear Cell, Cystadenocarcinoma, Serous.
- therapy : Adenocarcinoma, Clear Cell, Cystadenocarcinoma, Serous, Endometrial Neoplasms.
- Aged, Case-Control Studies, Female, Follow-Up Studies, Humans, Lymphatic Metastasis, Middle Aged, Neoplasm Grading, Neoplasm Invasiveness, Neoplasm Staging, Prognosis, Quality of Life, Survival Rate.

Abstract

About 15% of patients with endometrial cancer have high-risk features and are at increased risk of distant metastases and endometrial cancer-related death. We designed the PORTEC-3 trial to investigate the benefit of adjuvant chemoradiotherapy compared with radiotherapy alone for women with high-risk endometrial cancer.

DOI: 10.1016/S1470-2045(16)30120-6
PubMed: 27397040

Affiliations:

Le document en format XML

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<author><name sortKey="Haie Meder, Christine" sort="Haie Meder, Christine" uniqKey="Haie Meder C" first="Christine" last="Haie-Meder">Christine Haie-Meder</name>
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<author><name sortKey="Ledermann, Jonathan A" sort="Ledermann, Jonathan A" uniqKey="Ledermann J" first="Jonathan A" last="Ledermann">Jonathan A. Ledermann</name>
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<author><name sortKey="Khaw, Pearly" sort="Khaw, Pearly" uniqKey="Khaw P" first="Pearly" last="Khaw">Pearly Khaw</name>
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<author><name sortKey="Kitchener, Henry C" sort="Kitchener, Henry C" uniqKey="Kitchener H" first="Henry C" last="Kitchener">Henry C. Kitchener</name>
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<author><name sortKey="Nijman, Hans W" sort="Nijman, Hans W" uniqKey="Nijman H" first="Hans W" last="Nijman">Hans W. Nijman</name>
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<wicri:regionArea>Department of Gynaecologic Oncology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
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</placeName>
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<author><name sortKey="Kruitwagen, Roy F" sort="Kruitwagen, Roy F" uniqKey="Kruitwagen R" first="Roy F" last="Kruitwagen">Roy F. Kruitwagen</name>
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<wicri:regionArea>Department of Gynaecology and Obstetrics, and GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Nout, Remi A" sort="Nout, Remi A" uniqKey="Nout R" first="Remi A" last="Nout">Remi A. Nout</name>
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<author><name sortKey="Verhoeven Adema, Karen W" sort="Verhoeven Adema, Karen W" uniqKey="Verhoeven Adema K" first="Karen W" last="Verhoeven-Adema">Karen W. Verhoeven-Adema</name>
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<author><name sortKey="Smit, Vincent T" sort="Smit, Vincent T" uniqKey="Smit V" first="Vincent T" last="Smit">Vincent T. Smit</name>
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</placeName>
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<author><name sortKey="Putter, Hein" sort="Putter, Hein" uniqKey="Putter H" first="Hein" last="Putter">Hein Putter</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation>
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</placeName>
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<author><name sortKey="Creutzberg, Carien L" sort="Creutzberg, Carien L" uniqKey="Creutzberg C" first="Carien L" last="Creutzberg">Carien L. Creutzberg</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiation Oncology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Toxicity and quality of life after adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): an open-label, multicentre, randomised, phase 3 trial.</title>
<author><name sortKey="De Boer, Stephanie M" sort="De Boer, Stephanie M" uniqKey="De Boer S" first="Stephanie M" last="De Boer">Stephanie M. De Boer</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Radiation Oncology, Leiden University Medical Center, Leiden, Netherlands. Electronic address: s.m.de_boer.onco@lumc.nl.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiation Oncology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
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<author><name sortKey="Powell, Melanie E" sort="Powell, Melanie E" uniqKey="Powell M" first="Melanie E" last="Powell">Melanie E. Powell</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Oncology, Barts Health NHS Trust, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mileshkin, Linda" sort="Mileshkin, Linda" uniqKey="Mileshkin L" first="Linda" last="Mileshkin">Linda Mileshkin</name>
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<wicri:regionArea>Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, VIC</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Katsaros, Dionyssios" sort="Katsaros, Dionyssios" uniqKey="Katsaros D" first="Dionyssios" last="Katsaros">Dionyssios Katsaros</name>
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<wicri:regionArea>Department of Surgical Sciences, Gynecologic Oncology, Città della Salute and S Anna Hospital, University of Torino, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
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</placeName>
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<author><name sortKey="Bessette, Paul" sort="Bessette, Paul" uniqKey="Bessette P" first="Paul" last="Bessette">Paul Bessette</name>
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<wicri:regionArea>NCIC-CTG, Department of Obstetrics and Gynaecology, University of Sherbrooke, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Haie Meder, Christine" sort="Haie Meder, Christine" uniqKey="Haie Meder C" first="Christine" last="Haie-Meder">Christine Haie-Meder</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiotherapy, Institut Gustave Roussy, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ottevanger, Petronella B" sort="Ottevanger, Petronella B" uniqKey="Ottevanger P" first="Petronella B" last="Ottevanger">Petronella B. Ottevanger</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Radboudumc, Nijmegen, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Oncology, Radboudumc, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ledermann, Jonathan A" sort="Ledermann, Jonathan A" uniqKey="Ledermann J" first="Jonathan A" last="Ledermann">Jonathan A. Ledermann</name>
<affiliation wicri:level="3"><nlm:affiliation>Cancer Research UK and UCL Cancer Trials Centre, UCL Cancer Institute, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK and UCL Cancer Trials Centre, UCL Cancer Institute, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Khaw, Pearly" sort="Khaw, Pearly" uniqKey="Khaw P" first="Pearly" last="Khaw">Pearly Khaw</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Radiation Oncology & Cancer Imaging, Peter MacCallum Cancer Center, East Melbourne, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Radiation Oncology & Cancer Imaging, Peter MacCallum Cancer Center, East Melbourne, VIC</wicri:regionArea>
<wicri:noRegion>VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Colombo, Alessandro" sort="Colombo, Alessandro" uniqKey="Colombo A" first="Alessandro" last="Colombo">Alessandro Colombo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology, Azienda Ospedaliera della Provincia di Lecco, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Radiation Oncology, Azienda Ospedaliera della Provincia di Lecco</wicri:regionArea>
<wicri:noRegion>Azienda Ospedaliera della Provincia di Lecco</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fyles, Anthony" sort="Fyles, Anthony" uniqKey="Fyles A" first="Anthony" last="Fyles">Anthony Fyles</name>
<affiliation wicri:level="1"><nlm:affiliation>NCIC-CTG, Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>NCIC-CTG, Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baron, Marie Helene" sort="Baron, Marie Helene" uniqKey="Baron M" first="Marie-Helene" last="Baron">Marie-Helene Baron</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Radiotherapy, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiotherapy, Centre Hospitalier Régional Universitaire de Besançon, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
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<author><name sortKey="Kitchener, Henry C" sort="Kitchener, Henry C" uniqKey="Kitchener H" first="Henry C" last="Kitchener">Henry C. Kitchener</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer Sciences, University of Manchester, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Sciences, University of Manchester, Manchester</wicri:regionArea>
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<settlement type="city">Manchester</settlement>
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<orgName type="university">Université de Manchester</orgName>
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<author><name sortKey="Nijman, Hans W" sort="Nijman, Hans W" uniqKey="Nijman H" first="Hans W" last="Nijman">Hans W. Nijman</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Gynaecologic Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gynaecologic Oncology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
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<author><name sortKey="Kruitwagen, Roy F" sort="Kruitwagen, Roy F" uniqKey="Kruitwagen R" first="Roy F" last="Kruitwagen">Roy F. Kruitwagen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gynaecology and Obstetrics, and GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gynaecology and Obstetrics, and GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
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<author><name sortKey="Nout, Remi A" sort="Nout, Remi A" uniqKey="Nout R" first="Remi A" last="Nout">Remi A. Nout</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Radiation Oncology, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiation Oncology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Verhoeven Adema, Karen W" sort="Verhoeven Adema, Karen W" uniqKey="Verhoeven Adema K" first="Karen W" last="Verhoeven-Adema">Karen W. Verhoeven-Adema</name>
<affiliation wicri:level="3"><nlm:affiliation>Comprehensive Cancer Center The Netherlands, Leiden, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Comprehensive Cancer Center The Netherlands, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
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<author><name sortKey="Smit, Vincent T" sort="Smit, Vincent T" uniqKey="Smit V" first="Vincent T" last="Smit">Vincent T. Smit</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
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<author><name sortKey="Putter, Hein" sort="Putter, Hein" uniqKey="Putter H" first="Hein" last="Putter">Hein Putter</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Statistics, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
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</author>
<author><name sortKey="Creutzberg, Carien L" sort="Creutzberg, Carien L" uniqKey="Creutzberg C" first="Carien L" last="Creutzberg">Carien L. Creutzberg</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Radiation Oncology, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiation Oncology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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<series><title level="j">The Lancet. Oncology</title>
<idno type="eISSN">1474-5488</idno>
<imprint><date when="2016" type="published">2016</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma, Clear Cell (radiotherapy)</term>
<term>Adenocarcinoma, Clear Cell (secondary)</term>
<term>Adenocarcinoma, Clear Cell (therapy)</term>
<term>Aged</term>
<term>Antineoplastic Combined Chemotherapy Protocols (adverse effects)</term>
<term>Carboplatin (administration & dosage)</term>
<term>Case-Control Studies</term>
<term>Chemoradiotherapy, Adjuvant (adverse effects)</term>
<term>Cisplatin (administration & dosage)</term>
<term>Cystadenocarcinoma, Serous (radiotherapy)</term>
<term>Cystadenocarcinoma, Serous (secondary)</term>
<term>Cystadenocarcinoma, Serous (therapy)</term>
<term>Endometrial Neoplasms (pathology)</term>
<term>Endometrial Neoplasms (radiotherapy)</term>
<term>Endometrial Neoplasms (therapy)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Gastrointestinal Diseases (diagnosis)</term>
<term>Gastrointestinal Diseases (etiology)</term>
<term>Hematologic Diseases (diagnosis)</term>
<term>Hematologic Diseases (etiology)</term>
<term>Humans</term>
<term>Lymphatic Metastasis</term>
<term>Middle Aged</term>
<term>Neoplasm Grading</term>
<term>Neoplasm Invasiveness</term>
<term>Neoplasm Staging</term>
<term>Nervous System Diseases (diagnosis)</term>
<term>Nervous System Diseases (etiology)</term>
<term>Paclitaxel (administration & dosage)</term>
<term>Prognosis</term>
<term>Quality of Life</term>
<term>Radiotherapy, Adjuvant (adverse effects)</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Adénocarcinome à cellules claires ()</term>
<term>Adénocarcinome à cellules claires (radiothérapie)</term>
<term>Adénocarcinome à cellules claires (secondaire)</term>
<term>Carboplatine (administration et posologie)</term>
<term>Chimioradiothérapie adjuvante (effets indésirables)</term>
<term>Cisplatine (administration et posologie)</term>
<term>Cystadénocarcinome séreux ()</term>
<term>Cystadénocarcinome séreux (radiothérapie)</term>
<term>Cystadénocarcinome séreux (secondaire)</term>
<term>Femelle</term>
<term>Grading des tumeurs</term>
<term>Humains</term>
<term>Hémopathies (diagnostic)</term>
<term>Hémopathies (étiologie)</term>
<term>Invasion tumorale</term>
<term>Maladies du système nerveux (diagnostic)</term>
<term>Maladies du système nerveux (étiologie)</term>
<term>Maladies gastro-intestinales (diagnostic)</term>
<term>Maladies gastro-intestinales (étiologie)</term>
<term>Métastase lymphatique</term>
<term>Paclitaxel (administration et posologie)</term>
<term>Pronostic</term>
<term>Protocoles de polychimiothérapie antinéoplasique (effets indésirables)</term>
<term>Qualité de vie</term>
<term>Radiothérapie adjuvante (effets indésirables)</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Taux de survie</term>
<term>Tumeurs de l'endomètre ()</term>
<term>Tumeurs de l'endomètre (anatomopathologie)</term>
<term>Tumeurs de l'endomètre (radiothérapie)</term>
<term>Études cas-témoins</term>
<term>Études de suivi</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Carboplatin</term>
<term>Cisplatin</term>
<term>Paclitaxel</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Carboplatine</term>
<term>Cisplatine</term>
<term>Paclitaxel</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term>
<term>Chemoradiotherapy, Adjuvant</term>
<term>Radiotherapy, Adjuvant</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs de l'endomètre</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Gastrointestinal Diseases</term>
<term>Hematologic Diseases</term>
<term>Nervous System Diseases</term>
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<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hémopathies</term>
<term>Maladies du système nerveux</term>
<term>Maladies gastro-intestinales</term>
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<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Chimioradiothérapie adjuvante</term>
<term>Protocoles de polychimiothérapie antinéoplasique</term>
<term>Radiothérapie adjuvante</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gastrointestinal Diseases</term>
<term>Hematologic Diseases</term>
<term>Nervous System Diseases</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Endometrial Neoplasms</term>
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<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Adenocarcinoma, Clear Cell</term>
<term>Cystadenocarcinoma, Serous</term>
<term>Endometrial Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Adénocarcinome à cellules claires</term>
<term>Cystadénocarcinome séreux</term>
<term>Tumeurs de l'endomètre</term>
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<keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Adénocarcinome à cellules claires</term>
<term>Cystadénocarcinome séreux</term>
</keywords>
<keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Adenocarcinoma, Clear Cell</term>
<term>Cystadenocarcinoma, Serous</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Adenocarcinoma, Clear Cell</term>
<term>Cystadenocarcinoma, Serous</term>
<term>Endometrial Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hémopathies</term>
<term>Maladies du système nerveux</term>
<term>Maladies gastro-intestinales</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Lymphatic Metastasis</term>
<term>Middle Aged</term>
<term>Neoplasm Grading</term>
<term>Neoplasm Invasiveness</term>
<term>Neoplasm Staging</term>
<term>Prognosis</term>
<term>Quality of Life</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Adénocarcinome à cellules claires</term>
<term>Cystadénocarcinome séreux</term>
<term>Femelle</term>
<term>Grading des tumeurs</term>
<term>Humains</term>
<term>Invasion tumorale</term>
<term>Métastase lymphatique</term>
<term>Pronostic</term>
<term>Qualité de vie</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Taux de survie</term>
<term>Tumeurs de l'endomètre</term>
<term>Études cas-témoins</term>
<term>Études de suivi</term>
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<front><div type="abstract" xml:lang="en">About 15% of patients with endometrial cancer have high-risk features and are at increased risk of distant metastases and endometrial cancer-related death. We designed the PORTEC-3 trial to investigate the benefit of adjuvant chemoradiotherapy compared with radiotherapy alone for women with high-risk endometrial cancer.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Bourgogne-Franche-Comté</li>
<li>Franche-Comté</li>
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<orgName><li>Université de Manchester</li>
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<tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="De Boer, Stephanie M" sort="De Boer, Stephanie M" uniqKey="De Boer S" first="Stephanie M" last="De Boer">Stephanie M. De Boer</name>
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<name sortKey="Creutzberg, Carien L" sort="Creutzberg, Carien L" uniqKey="Creutzberg C" first="Carien L" last="Creutzberg">Carien L. Creutzberg</name>
<name sortKey="Kruitwagen, Roy F" sort="Kruitwagen, Roy F" uniqKey="Kruitwagen R" first="Roy F" last="Kruitwagen">Roy F. Kruitwagen</name>
<name sortKey="Nijman, Hans W" sort="Nijman, Hans W" uniqKey="Nijman H" first="Hans W" last="Nijman">Hans W. Nijman</name>
<name sortKey="Nout, Remi A" sort="Nout, Remi A" uniqKey="Nout R" first="Remi A" last="Nout">Remi A. Nout</name>
<name sortKey="Ottevanger, Petronella B" sort="Ottevanger, Petronella B" uniqKey="Ottevanger P" first="Petronella B" last="Ottevanger">Petronella B. Ottevanger</name>
<name sortKey="Putter, Hein" sort="Putter, Hein" uniqKey="Putter H" first="Hein" last="Putter">Hein Putter</name>
<name sortKey="Smit, Vincent T" sort="Smit, Vincent T" uniqKey="Smit V" first="Vincent T" last="Smit">Vincent T. Smit</name>
<name sortKey="Verhoeven Adema, Karen W" sort="Verhoeven Adema, Karen W" uniqKey="Verhoeven Adema K" first="Karen W" last="Verhoeven-Adema">Karen W. Verhoeven-Adema</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Powell, Melanie E" sort="Powell, Melanie E" uniqKey="Powell M" first="Melanie E" last="Powell">Melanie E. Powell</name>
</region>
<name sortKey="Kitchener, Henry C" sort="Kitchener, Henry C" uniqKey="Kitchener H" first="Henry C" last="Kitchener">Henry C. Kitchener</name>
<name sortKey="Ledermann, Jonathan A" sort="Ledermann, Jonathan A" uniqKey="Ledermann J" first="Jonathan A" last="Ledermann">Jonathan A. Ledermann</name>
</country>
<country name="Australie"><noRegion><name sortKey="Mileshkin, Linda" sort="Mileshkin, Linda" uniqKey="Mileshkin L" first="Linda" last="Mileshkin">Linda Mileshkin</name>
</noRegion>
<name sortKey="Khaw, Pearly" sort="Khaw, Pearly" uniqKey="Khaw P" first="Pearly" last="Khaw">Pearly Khaw</name>
</country>
<country name="Italie"><region name="Piémont"><name sortKey="Katsaros, Dionyssios" sort="Katsaros, Dionyssios" uniqKey="Katsaros D" first="Dionyssios" last="Katsaros">Dionyssios Katsaros</name>
</region>
<name sortKey="Colombo, Alessandro" sort="Colombo, Alessandro" uniqKey="Colombo A" first="Alessandro" last="Colombo">Alessandro Colombo</name>
</country>
<country name="Canada"><noRegion><name sortKey="Bessette, Paul" sort="Bessette, Paul" uniqKey="Bessette P" first="Paul" last="Bessette">Paul Bessette</name>
</noRegion>
<name sortKey="Fyles, Anthony" sort="Fyles, Anthony" uniqKey="Fyles A" first="Anthony" last="Fyles">Anthony Fyles</name>
</country>
<country name="France"><noRegion><name sortKey="Haie Meder, Christine" sort="Haie Meder, Christine" uniqKey="Haie Meder C" first="Christine" last="Haie-Meder">Christine Haie-Meder</name>
</noRegion>
<name sortKey="Baron, Marie Helene" sort="Baron, Marie Helene" uniqKey="Baron M" first="Marie-Helene" last="Baron">Marie-Helene Baron</name>
</country>
</tree>
</affiliations>
</record>

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Toxicity and quality of life after adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): an open-label, multicentre, randomised, phase 3 trial.

Toxicity and quality of life after adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): an open-label, multicentre, randomised, phase 3 trial.

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